Endocrine Abstracts

Cross-sectional and prospective data reveals significant dose-wise health-risk reductions with higher vitamin D status, each with proven mechanistic explanations. RCT causality confirmation is sparse but support is emerging with better appreciation of vitamin D’s biology. Confounding factors in vitamin D RCT design include that nutrients are not pharmaceuticals [increases in serum 25(OH)D concentrations and efficacy with supplementation of deficiency are ‘S’-sha...

Background: Hypovitaminosis D is associated with T2DM risk, cross-sectionally and prospectively; supplementation can reduce insulin resistance and increase glucose-induced insulin secretion in humans. Increased pancreatic islet RAS activity is induced by hyperglycemia, enhancing β cell damage (Leung PS et al.). Vitamin D is now known to suppress renin secretion, thus we have examined effects of calcitriol on increased islet RAS activity in vitro±hyp...